yasyAsIt kuladaivatam raghuvareNArAdhita: shrIsakha:
	kAverisaridantarIpanagarI vAsasthalI puNyabhU: |
kR^iShNo mAnyagururvareNyamahimA vedAntavidyAnidhi:
	bhrAtA saumyavara: svayamcha bhuvanAchAryosi kaste sama: ||

Meaning:

kuladaivatam 			- The Kula Devata (Sri Ranganatha)
raghuvareNa ArAdhita: 		- was prayed to by Sri Rama and
shrIsakha: 			- is the consort of Sriranga Nachchiyar;
vAsasthalI 			- the residing place is
kAverisarit antarIpa nagarI 	- Srirangam that is amidst the Kaveri river,
puNyabhU: 			- and is the land where good deeds grow;
kR^iShNa: 			- (the father is) Vadakku Thiruveedhi Pillai,
vareNya mahimA 			- who has great fame
mAnya guru: 			- who is the acharya worthy of being prayed to,
vedAnta vidyA nidhi: 		- and who has the wealth of the Sanskrit and Tamil Vedantas;
bhrAtA 				- the brother is
saumya vara: 			- Azhagiya Manavala Perumal Nayanar;
svayamcha 			- you yourself
asi 				- became
bhuvanAchArya: 			- acharya to this world.
tasyatesama: ka: 		- To such a person who is equal?

Vyakhyana Saram:
In this shloka, Swami Desikan shows the different types of greatness associated with Pillai Lokacharyar.

Pillai Lokacharyar's family deity is none other than Sri Ranaganatha - who is the first amongst the 108 divyadesa deities and who was personally worshipped by Sri Rama Himself.

The place he resides is the lofty Srirangam where good deeds automatically grow and sins are removed.

His father is the renowned Vadakku Thiruveedhi Pillai, the disciple of Nampillai who himself was Lokacharya.

His brother is Azhagiya Manavala Perumal Nayanar, the author of the great work Acharya Hrudayam.

Other than being associated with such great people, he himself is called Pillai Lokacharyar - a most apt name for him.

Vedanta Desikan is asking who can equal such a personality.